Receiving MONJUVI Treatment schedule Staying on treatment Possible side effects

Receiving MONJUVI

Where can I receive MONJUVI?

MONJUVI is outpatient treatment. You can receive MONJUVI in a nearby clinic or infusion center. This means you can choose to stay with your current healthcare team and begin treatment as soon as you’re ready.

MONJUVI is given along with lenalidomide, a once-daily oral capsule, throughout the first year of treatment. Lenalidomide is another kind of medicine that helps the immune system respond to cancer. Taking MONJUVI and lenalidomide together may help treat your relapsed or refractory DLBCL.

Is MONJUVI right for you?

Understanding how a medicine works is only one part of choosing a treatment. Your comfort level with the treatment process is another important aspect to consider as you talk with your healthcare team about your next step.

How will I receive my treatment?

MONJUVI will be given to you by your healthcare provider as an intravenous (IV) infusion into one of your veins. You will receive MONJUVI in a clinic or infusion center, so there’s no need to travel to a special cancer center.

Your doctor will also prescribe a 25-mg lenalidomide capsule for you to take orally once a day on days 1 to 21 of each treatment cycle, for the first 12 cycles.

Your healthcare provider will give you medicines before each infusion to decrease your chance of infusion reactions. If you do not have any reactions, your healthcare provider may decide that you do not need these medicines with later infusions. It is important to take these medicines as directed by your healthcare team.

Following premedication, your first infusion will take about 1 ½ to 2 ½ hours. Your infusion time may vary if your healthcare team needs to make adjustments during treatment. Nurses and other healthcare professionals will be available to help you during your treatment.

After that, the infusion time will be between 90 minutes and 2 hours.

Your healthcare team may need to delay or completely stop treatment with MONJUVI if you have severe side effects.

Your treatment schedule

 Cycle 1
You will receive MONJUVI on 5 days during your first cycle. Each cycle lasts for 28 days.
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DAYS 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
MONJUVI 12 mg/kg ■ ■ ■ ■ ■
Lenalidomide 25 mg daily ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
 Cycles 2 and 3
For your second and third cycles, you will receive MONJUVI on 4 days.
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DAYS 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
MONJUVI 12 mg/kg ■ ■ ■ ■
Lenalidomide 25 mg daily ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
 Cycles 4 to 12
After your first 3 cycles, you will receive MONJUVI once every 2 weeks.
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DAYS 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
MONJUVI 12 mg/kg ■ ■
Lenalidomide 25 mg daily ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●
 Cycle 13 and after
After 12 cycles, you will receive only MONJUVI as maintenance therapy.
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DAYS 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28
MONJUVI 12 mg/kg ■ ■
Cycle 1 You will receive MONJUVI on 5 days during your first cycle. Each cycle lasts for 28 days.
MONJUVI 12 mg/kg on days 1, 4, 8, 15, 22
Lenalidomide 25 mg daily by mouth on days 1 to 21
Cycles 2 and 3 For your second and third cycles, you will receive MONJUVI on 4 days.
MONJUVI 12 mg/kg on days 1, 8, 15, 22
Lenalidomide 25 mg daily by mouth on days 1 to 21
Cycles 4 to 12 After your first 3 cycles, you will receive MONJUVI once every 2 weeks.
MONJUVI 12 mg/kg on days 1, 15
Lenalidomide 25 mg daily by mouth on days 1 to 21
Cycle 13 and after After 12 cycles, you will receive only MONJUVI as maintenance therapy.
MONJUVI 12 mg/kg on days 1, 15

Treatment may continue for as long as you and your healthcare team choose, or until your disease progresses. Your healthcare team will monitor and may adjust your dose of lenalidomide as needed throughout your treatment.

If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment.

Knowing and understanding your treatment schedule is important. You and your healthcare team can build a personalized schedule for your treatment with MONJUVI and lenalidomide.

Staying on treatment gives you a chance to reach and maintain remission

Because of the way MONJUVI works with your immune system, treatment is given on a long-term basis to help you achieve and maintain control of your disease.

How long did it take to reach remission?

In a clinical study of MONJUVI and lenalidomide, half of the people in the study achieved either complete or partial remission within the first 2 months of treatment (range 1.7–34.7 months).

This means that for many people, it may take longer than 2 months to reach remission, so it is important to stay on treatment as directed by your doctor.

Although the study was not designed to find out the length of time it took for people to achieve a response, these results were observed.

Common side effects

It is important for you to write down how you are feeling and any side effects you may be experiencing. Make sure you talk to your healthcare team about these side effects.

The most common side effects of MONJUVI include:

Feeling tired or
weak

Diarrhea

Cough

Fever

Swelling of lower
legs or hands

Respiratory tract
infection

Decreased appetite

These are not all the possible side effects of MONJUVI. Call your doctor for medical advice about side effects.

Infusion-related reactions can occur at any time during treatment but are more frequent at the beginning of treatment. Your healthcare team may delay or completely stop your infusion and may also give you other medicines if you have severe side effects.

Tell your healthcare team right away if you get:

  • Fever, chills, flushing, headache, or shortness of breath during an infusion of MONJUVI

  • A fever of 100.4 °F (38 °C) or above, or any bruising or bleeding

  • A fever of 100.4 °F (38 °C) or above, or develop any signs or symptoms of an infection

Your healthcare provider will monitor your blood counts prior to each infusion and throughout your treatment with MONJUVI.

Talking with your healthcare team

Gather your thoughts and questions

There’s a lot you’ll want to know about treatment with MONJUVI. Each appointment you have is a good opportunity to ask questions. Write down your thoughts before you go to help you make the most of the time you spend with your doctor and healthcare team. Also, keep track of how you are feeling during your treatment, and make sure to discuss this at your next appointment.

Download MONJUVI Treatment Journal

The MONJUVI Treatment Journal can help you log important information that you want to share with your healthcare team.

Download Journal

Learn more about the resources available to help you and your caregivers.

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